Article
Microarray analysis of LIF/Stat3 transcriptional targets in embryonic stem cells.
Stem cells (Dayton, Ohio) - 1 Jan 2000
Sekkaï Dalila, Gruel Gaëtan, Herry Magali, Moucadel Virginie, Constantinescu Stefan N, Albagli Olivier, Tronik-Le Roux Diana, Vainchenker William, Bennaceur-Griscelli Annelise
Abstract excerpt
Mouse embryonic stem (ES) cells can be propagated in vitro while retaining their properties of pluripotency and self-renewal under the continuous presence of leukemia inhibitor factor (LIF). An essential role has been attributed to subsequent activation of the Stat3 transcription factor in mediating LIF self-renewal response. To date, however, downstream target genes of Stat3 in ES cells are still unknown. To...
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