Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

<i>Lefty</i> at the Crossroads of “Stemness” and Differentiative Events

26 May 2006

Abstract excerpt

Stem cells are functionally defined by their ability to self-renew and generate a progeny capable of creation or reconstitution of various tissues. Microarray analysis has shown a member of the transforming growth factor (TGF)-beta superfamily, Lefty, to be the single most abundant inhibitor in stem cells and in maternal decidua that supports embryo implantation. Lefty is regulated by pathways such as Smad (Sma...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pluripotent Stem Cells Research
Share to Reproductive Biology and Fertility
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16728558
DOI: 10.1634/stemcells.2006-0075

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

<i>Lefty</i> at the Crossroads of “Stemness” and Differentiative EventsPMID 16728558Read ↗

SALL4: engine of cell stemness.Semantic proximity Read ↗

Identifying regulators of neural stem cell fate and tumourigenesisSemantic proximity Read ↗

<i>Platr4</i> is an ESC-specific lncRNA that exhibits its function downstream on meso/endoderm lineage commitmentSemantic proximity Read ↗

Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoidsSemantic proximity Read ↗

Expression of Nodal, Lefty-A, and Lefty-B in Undifferentiated Human Embryonic Stem Cells Requires Activation of Smad2/3Semantic proximity Read ↗

TGF-β modulates cell fate in human ES cell-derived foregut endoderm by inhibiting multiple endogenous signaling pathwaysSemantic proximity Read ↗

A <i>Nanog</i> -dependent gene cluster initiates the specification of the pluripotent epiblastSemantic proximity Read ↗

A miRNA screen identifies a transcriptional program controlling the fate of adult stem cellSemantic proximity Read ↗

Activin/nodal signalling controls the epigenome and epitranscriptome of human pluripotent stem cellsSemantic proximity Read ↗

Decoding the activated stem cell phenotype of the vividly maturing neonatal pituitarySemantic proximity Read ↗

Integrative genome-scale analyses reveal post-transcriptional signatures of early human small intestinal development in a directed differentiation organoid modelSemantic proximity Read ↗

Single-cell RNA sequencing identifies CXADR as a fate determinant of the placental exchange surfaceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.