Article

SMURF2 phosphorylation at Thr249 modifies the stemness and tumorigenicity of glioma stem cells by regulating TGF-β receptor stability

2021-06-22

Abstract excerpt

<title>Abstract</title> <p>Glioma stem cells (GSCs) contribute to the pathogenesis of glioblastoma, the most malignant form of glioma. The implication and underlying mechanisms of SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) on the GSC phenotypes remain unknown. We previously demonstrated that SMURF2 phosphorylation at Thr249 (SMURF2Thr249) activates its E3 ubiquitin ligase activity. Here, we demonstrate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0cfdbf6c-9d7b-5a51-bad1-a36ed5f05fa7
DOI: 10.21203/rs.3.rs-612377/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SMURF2 phosphorylation at Thr249 modifies the stemness and tumorigenicity of glioma stem cells by regulating TGF-β receptor stabilityDOI 10.21203/rs.3.rs-612377/v1Read

SMURF2 phosphorylation at Thr249 modifies glioma stemness and tumorigenicity by regulating TGF-β receptor stability.Semantic proximity Read

SMURF2 phosphorylation at Thr249 modifies the stemness and tumorigenicity of glioma stem cells by regulating TGF-β receptor stabilitySemantic proximity Read

Reciprocal regulation of integrin β4 and KLF4 promotes gliomagenesis through maintaining cancer stem cell traitsSemantic proximity Read

Smurfs in Protein Homeostasis, Signaling, and CancerSemantic proximity Read

The ubiquitin ligase Smurf2 suppresses TGFβ-induced epithelial–mesenchymal transition in a sumoylation-regulated mannerSemantic proximity Read

DYRK1A Negatively Regulates CDK5-SOX2 Pathway and Self-Renewal of Glioblastoma Stem CellsSemantic proximity Read

The Post-translational Modifications of Smurf2 in TGF-β SignalingSemantic proximity Read

Oncogenic Smurf1 promotes PTEN wild-type glioblastoma growth by mediating PTEN ubiquitylation.Semantic proximity Read

Up-regulation of miR-663a inhibits the cancer stem cell-like properties of glioma via repressing the KDM2A-mediated TGF-β/SMAD signaling pathwaySemantic proximity Read

TGFBR2 <sup>High</sup> mesenchymal glioma stem cells phenocopy regulatory T cells to suppress CD4+ and CD8+ T cell functionSemantic proximity Read

TRIM 8 regulates stemness in glioblastoma through PIAS 3‐ STAT 3Semantic proximity Read

TRIM24 promotes stemness and invasiveness of glioblastoma cells via activating Sox2 expressionSemantic proximity Read