Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SMURF2 phosphorylation at Thr249 modifies glioma stemness and tumorigenicity by regulating TGF-β receptor stability.

Communications biology - 11 Jan 2022

Hiraiwa Manami, Fukasawa Kazuya, Iezaki Takashi, Sabit Hemragul, Horie Tetsuhiro, Tokumura Kazuya, Iwahashi Sayuki, Murata Misato, Kobayashi Masaki, Suzuki Akane, Park Gyujin, Kaneda Katsuyuki, Todo Tomoki, Hirao Atsushi, Nakada Mitsutoshi, Hinoi Eiichi

Abstract excerpt

Glioma stem cells (GSCs) contribute to the pathogenesis of glioblastoma, the most malignant form of glioma. The implication and underlying mechanisms of SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) on the GSC phenotypes remain unknown. We previously demonstrated that SMURF2 phosphorylation at Thr249 (SMURF2Thr249) activates its E3 ubiquitin ligase activity. Here, we demonstrate that SMURF2Thr249...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Glioblastoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to Mice, Nude

Share to Phosphorylation

Share to Receptors, Transforming Growth Factor beta

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 35017630
DOI: 10.1038/s42003-021-02950-0
PMCID: PMC8752672

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SMURF2 phosphorylation at Thr249 modifies glioma stemness and tumorigenicity by regulating TGF-β receptor stability.PMID 35017630Read ↗

SMURF2 phosphorylation at Thr249 modifies the stemness and tumorigenicity of glioma stem cells by regulating TGF-β receptor stabilitySemantic proximity Read ↗

SMURF2 phosphorylation at Thr249 modifies the stemness and tumorigenicity of glioma stem cells by regulating TGF-β receptor stabilitySemantic proximity Read ↗

Reciprocal regulation of integrin β4 and KLF4 promotes gliomagenesis through maintaining cancer stem cell traitsSemantic proximity Read ↗

Smurfs in Protein Homeostasis, Signaling, and CancerSemantic proximity Read ↗

The ubiquitin ligase Smurf2 suppresses TGFβ-induced epithelial–mesenchymal transition in a sumoylation-regulated mannerSemantic proximity Read ↗

Oncogenic Smurf1 promotes PTEN wild-type glioblastoma growth by mediating PTEN ubiquitylation.Semantic proximity Read ↗

The Post-translational Modifications of Smurf2 in TGF-β SignalingSemantic proximity Read ↗

DYRK1A Negatively Regulates CDK5-SOX2 Pathway and Self-Renewal of Glioblastoma Stem CellsSemantic proximity Read ↗

TRIM 8 regulates stemness in glioblastoma through PIAS 3‐ STAT 3Semantic proximity Read ↗

TGFBR2 <sup>High</sup> mesenchymal glioma stem cells phenocopy regulatory T cells to suppress CD4+ and CD8+ T cell functionSemantic proximity Read ↗

Up-regulation of miR-663a inhibits the cancer stem cell-like properties of glioma via repressing the KDM2A-mediated TGF-β/SMAD signaling pathwaySemantic proximity Read ↗

TGFBR2High Mesenchymal Glioma Stem Cells Phenocopy Regulatory T Cells to Suppress CD4+ and CD8+ T Cell FunctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.