Article
Oncogenic Smurf1 promotes PTEN wild-type glioblastoma growth by mediating PTEN ubiquitylation.
Oncogene - 1 Sept 2020
Xia Qin, Zhang Hanwen, Zhang Pei, Li Yang, Xu Mengchuan, Li Xiaobo, Li Xuejun, Dong Lei
Abstract excerpt
PI3K/Akt/mTOR signaling pathway activity is highly elevated in glioblastoma (GBM). Although rapamycin is known to inhibit this pathway, GBM patients are resistant to rapamycin monotherapy. This may be related to mutations of tumor suppressor phosphatase and tensin homolog (PTEN). Here, we show that higher expression of E3 ligase Smad ubiquitylation regulatory factor 1 (Smurf1) in GBM is correlated with poor...
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