Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intracellular proton regulation of ClC-0.

The Journal of general physiology - 1 Jul 2008

Zifarelli Giovanni, Murgia Anna Rosa, Soliani Paolo, Pusch Michael

Abstract excerpt

Some CLC proteins function as passive Cl(-) ion channels whereas others are secondary active chloride/proton antiporters. Voltage-dependent gating of the model Torpedo channel ClC-0 is modulated by intracellular and extracellular pH, possibly reflecting a mechanistic relationship with the chloride/proton coupling of CLC antiporters. We used inside-out patch clamp measurements and mutagenesis to explore the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chloride Channels
Share to Chlorides
Share to Electric Stimulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Electrophysiology

Share to Ion Channel Gating

Share to Protons

Share to Torpedo

Share to Xenopus

Source

Open in PubMed Open full text

Identifiers

PMID: 18591423
DOI: 10.1085/jgp.200809999
PMCID: PMC2442169

Genes

CLC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intracellular proton regulation of ClC-0.PMID 18591423Read ↗

The role of protons in fast and slow gating of the Torpedo chloride channel ClC-0.Semantic proximity Read ↗

Insights into CLC-0's Slow-Gating from Intracellular Proton Inhibition.Semantic proximity Read ↗

Proton-dependent inhibition, inverted voltage activation, and slow gating of CLC-0 Chloride Channel.Semantic proximity Read ↗

Proton sensing of CLC-0 mutant E166D.Semantic proximity Read ↗

Analysis of a protein region involved in permeation and gating of the voltage-gated Torpedo chloride channel ClC-0.Semantic proximity Read ↗

Gating of the voltage-dependent chloride channel CIC-0 by the permeant anion.Semantic proximity Read ↗

Chloride dependence of hyperpolarization-activated chloride channel gates.Semantic proximity Read ↗

Voltage-dependent and -independent titration of specific residues accounts for complex gating of a ClC chloride channel by extracellular protons.Semantic proximity Read ↗

Ion transit pathways and gating in ClC chloride channels.Semantic proximity Read ↗

Proton selective conductance and gating of lysosomal cation channel TMEM175Semantic proximity Read ↗

Structure of the CLC-1 chloride channel from Homo sapiens.Semantic proximity Read ↗

Temperature dependence of fast and slow gating relaxations of ClC-0 chloride channels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.