Intracellular proton regulation of ClC-0.

doi:10.1085/jgp.200809999

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Article

Intracellular proton regulation of ClC-0.

The Journal of general physiology - 1 Jul 2008

Zifarelli Giovanni, Murgia Anna Rosa, Soliani Paolo, Pusch Michael

Abstract excerpt

Some CLC proteins function as passive Cl(-) ion channels whereas others are secondary active chloride/proton antiporters. Voltage-dependent gating of the model Torpedo channel ClC-0 is modulated by intracellular and extracellular pH, possibly reflecting a mechanistic relationship with the chloride/proton coupling of CLC antiporters. We used inside-out patch clamp measurements and mutagenesis to explore the...

Topics

Algorithms
Amino Acid Substitution
Animals
Chloride Channels
Chlorides
Deuterium Oxide
Electric Stimulation
Electrophysiology
Female
Hydrogen-Ion Concentration
Ion Channel Gating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kinetics

Models, Molecular

Mutation

Oocytes

Patch-Clamp Techniques

Protons

Recombinant Proteins

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PMID: 18591423
DOI: 10.1085/jgp.200809999
PMCID: PMC2442169

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