Article
The role of protons in fast and slow gating of the Torpedo chloride channel ClC-0.
European biophysics journal : EBJ - 1 May 2010
Zifarelli Giovanni, Pusch Michael
Abstract excerpt
Transmembrane proton transport is of fundamental importance for life. The list of H(+) transporting proteins has been recently expanded with the discovery that some members of the CLC gene family are stoichiometrically coupled Cl(-)/H(+) antiporters. Other CLC proteins are instead passive Cl(-) selective anion channels. The gating of these CLC channels is, however, strongly regulated by pH, likely reflecting the...
Topics
- Animals
- Chloride Channels
- Hydrogen-Ion Concentration
- Ion Channel Gating
- Ions
- Membrane Potentials
- Mutagenesis, Site-Directed
- Mutation
- Protons
- Torpedo