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Article

Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein.

Glia - 15 Aug 2007

Zhang Wei, Dallas Shannon, Zhang Dan, Guo Jian-Ping, Pang Hao, Wilson Belinda, Miller David S, Chen Biao, Zhang Wanqin, McGeer Patrick L, Hong Jau-Shyong, Zhang Jing

Abstract excerpt

alpha-Synuclein, a gene whose mutations, duplication, and triplication has been linked to autosomal dominant familial Parkinson's disease (fPD), appears to play a central role in the pathogenesis of sporadic PD (sPD) as well. Enhancement of neurodegeneration induced by mutant alpha-synuclein has...

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PMID: 17600340
DOI: 10.1002/glia.20532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17600340-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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