Article

Neutrophil Reprogramming Underlie Vasculopathy and Lung Disease in Systemic Sclerosis

2025-02-17

Abstract excerpt

The role of neutrophils in systemic sclerosis (SSc) remains incompletely understood. To address this, blood samples from 39 SSc patients, 39 healthy controls, and 22 systemic lupus erythematosus (SLE) patients were analyzed. In SSc, neutrophils exhibited substantial activation, evidenced by granule mobilization, elevated plasma levels of Neutrophil Extracellular Trap (NET) byproducts, and upregulated TIE2 expressi...

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Literature Corpus work: b375a54e-0adb-5fbf-9f1e-fed0e8a6d164
DOI: 10.1101/2025.02.12.637866

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