Neutrophil subsets and their gene signature associate with vascular inflammation and coronary atherosclerosis in lupus.

doi:10.1172/jci.insight.99276

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Article

Neutrophil subsets and their gene signature associate with vascular inflammation and coronary atherosclerosis in lupus.

JCI insight - 19 Apr 2018

Carlucci Philip M, Purmalek Monica M, Dey Amit K, Temesgen-Oyelakin Yenealem, Sakhardande Simantini, Joshi Aditya A, Lerman Joseph B, Fike Alice, Davis Michael, Chung Jonathan H, Playford Martin P, Naqi Mohammad, Mistry Pragnesh, Gutierrez-Cruz Gustavo, Dell'Orso Stefania, Naz Faiza, Salahuddin Taufiq, Natarajan Balaji, Manna Zerai, Tsai Wanxia L, Gupta Sarthak, Grayson Peter, Teague Heather, Chen Marcus Y, Sun Hong-Wei, Hasni Sarfaraz, Mehta Nehal N, Kaplan Mariana J

Abstract excerpt

BACKGROUND: Systemic lupus erythematosus (SLE) is associated with enhanced risk of atherosclerotic cardiovascular disease not explained by Framingham risk score (FRS). Immune dysregulation associated to a distinct subset of lupus proinflammatory neutrophils (low density granulocytes; LDGs) may play key roles in conferring enhanced CV risk. This study assessed if lupus LDGs are associated with in vivo vascular...

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Identifiers

PMID: 29669944
DOI: 10.1172/jci.insight.99276
PMCID: PMC5931124

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