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METTL3 promotes cell-cycle progression via activation of transcriptional elongation.

Molecular cell - 20 Aug 2026

Akçaöz-Alasar Azime, Wang Yanhua, Li Hang, Ostapenko Denis, Ramírez Parrado Carlos A, Villalobos Daniela, Li Wenxue, Boddu Prajwal C, Nguyen Alexander H, Li Hengyi, Perez-Pepe Marcelo, Darnat Pénélope, Akgül Bünyamin, Pillai Manoj M, Liu Yansheng, Kabeche Lilian, Alarcón Claudio R

Abstract excerpt

Transcriptional elongation undergoes extensive remodeling at mitotic entry, yet how elongation control is integrated into core cell-cycle kinase networks remains unclear. Here, we identify the m6A methyltransferase METTL3 as a direct substrate of the mitotic kinase CDK1 in mammalian cells. CDK1-dependent phosphorylation of METTL3 at Ser43 is sharply induced at mitotic entry and promotes m6A methylation of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42537642
DOI: 10.1016/j.molcel.2026.07.011

Genes

METTL3
CDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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