Article

Genetically nominated cardiovascular-kidney-metabolic features are not preferentially responsive to weight-loss and cardiometabolic interventions

2026-07-30

Abstract excerpt

<h4>Background</h4> Substantial cardiovascular and kidney risk persists after successful weight loss. Whether features that genetics implicates in cardiovascular-kidney-metabolic (CKM) disease show larger short-term responses to weight-loss and cardiometabolic interventions than other features is unknown. <h4>Methods</h4> Across four molecular layers (proteome, transcriptome, methylome, metabolome), we applied l...

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Literature Corpus work: 0c93403d-aaf5-5195-8c2f-4992d9e6e3a3
DOI: 10.64898/2026.07.27.26358659

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