Article

A clustering approach to improve our understanding of the genetic and phenotypic complexity of chronic kidney disease

2023-10-13

Abstract excerpt

Chronic kidney disease (CKD) is a complex disorder that causes a gradual loss of kidney function, affecting approximately 9.1% of the world’s population. Here, we use a soft-clustering algorithm to deconstruct its genetic heterogeneity. First, we selected 322 CKD-associated independent genetic variants from published genome-wide association studies (GWAS) and added association results for 229 traits from the GWAS...

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Literature Corpus work: b9c74875-9d50-5682-ac5c-b1d7f09bb31a
DOI: 10.1101/2023.10.12.23296926

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