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Beyond event-rate enrichment: proteomic risk scores for mechanism-aware prevention trial design

2026-06-10

Abstract excerpt

<h4>Background</h4> Blood-based biomarkers are increasingly proposed for identifying high-risk individuals before clinical disease and for making prevention-oriented trials more efficient. Prognostic enrichment can increase event rates, but trial efficiency also depends on whether the intervention effect is preserved in the enriched population. <h4>Methods</h4> Using the UK Biobank Pharma Proteomics Project, we...

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Literature Corpus work
2bcc5edd-5c84-5513-ac9c-3d25697b8005
DOI
10.64898/2026.06.09.26355266
Open publication

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Beyond event-rate enrichment: proteomic risk scores for mechanism-aware prevention trial designDOI 10.64898/2026.06.09.26355266
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