Article

DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin

2024-02-07

Abstract excerpt

<h4>SUMMARY</h4> The proto-oncogene c-MYC is a key representative of the MYC transcription factor network regulating growth and metabolism. MML-1 (Myc- and Mondo-like) is its homolog in C. elegans . The functional and molecular cooperation between c-MYC and H3 lysine 79 methyltransferase DOT1L was demonstrated in several human cancer types, and we have earlier discovered the connection between C. elegans MML-1...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8b8d9f45-f194-54b0-82bf-38998488a23f
DOI: 10.1101/2024.02.06.579191

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatinDOI 10.1101/2024.02.06.579191Read

Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancerSemantic proximity Read

DOT1L Complex Regulates Transcriptional Initiation in Human CellsSemantic proximity Read

The mechanism of cross-talk between histone H2B ubiquitination and H3 methylation by Dot1LSemantic proximity Read

DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progressionSemantic proximity Read

The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure.Semantic proximity Read

Proximity labeling reveals a new <i>in vivo</i> network of interactors for the histone demethylase KDM5Semantic proximity Read

The Histone Methyltransferase DOT1L Promotes Neuroblastoma by Regulating Gene TranscriptionSemantic proximity Read

Comprehensive pan-cancer in tumors of human with tumor suppressor ZMYND11 geneSemantic proximity Read

Profiling the methylome targets of the histone lysine methyltransferase DOT1LSemantic proximity Read

Epigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activitySemantic proximity Read

Modular HUWE1 architecture serves as hub for degradation of cell-fate decision factorsSemantic proximity Read

Histone H3 lysine 4 methyltransferase KMT2D.Semantic proximity Read