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Generation and characterisation of <i>P. falciparum</i> parasites with a G358S mutation in the PfATP4 Na <sup>+</sup> pump and clinically relevant levels of resistance to some PfATP4 inhibitors

2022-01-12

Abstract excerpt

Small-molecule inhibitors of PfATP4, a Plasmodium falciparum protein that is believed to pump Na + out of the parasite while importing H + , are on track to become much-needed new antimalarial drugs. The spiroindolone cipargamin is poised to become the first PfATP4 inhibitor to reach the field, having performed strongly in Phase 1 and 2 clinical trials. Previous attempts to generate cipargamin-resistant parasit...

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Literature Corpus work
fce6eccb-83ae-5b2f-ae93-138ac377cb5b
DOI
10.1101/2022.01.11.475938
Open publication

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Generation and characterisation of <i>P. falciparum</i> parasites with a G358S mutation in the PfATP4 Na <sup>+</sup> pump and clinically relevant levels of resistance to some PfATP4 inhibitorsDOI 10.1101/2022.01.11.475938
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