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Article

Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines.

Nature communications - 12 Jan 2021

Sharma Manmohan, Malhotra Nipun, Yogavel Manickam, Harlos Karl, Melillo Bruno, Comer Eamon, Gonse Arthur, Parvez Suhel, Mitasev Branko, Fang Francis G, Schreiber Stuart L, Sharma Amit

Abstract excerpt

The inhibition of Plasmodium cytosolic phenylalanine tRNA-synthetase (cFRS) by a novel series of bicyclic azetidines has shown the potential to prevent malaria transmission, provide prophylaxis, and offer single-dose cure in animal models of malaria. To date, however, the molecular basis of Plasmodium cFRS inhibition by bicyclic azetidines has remained unknown. Here, we present structural and biochemical evidence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33436639
DOI: 10.1038/s41467-020-20478-5
PMCID: PMC7803973

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