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Virus-free continuous directed evolution in human cells using somatic hypermutation

2024-12-25

Abstract excerpt

The B cells of the human immune system have evolved somatic hypermutation (SHM) mechanisms that introduce mutations at the immunoglobulin genomic loci at a significantly higher frequency than the rest of the genome thereby allowing them to evolve antibody sequences without compromising fitness due to genome-wide mutations. Inspired by these observations, here we developed a continuous directed evolution platform i...

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Literature Corpus work
0bc53494-b242-52d9-8859-541b53d68f3d
DOI
10.1101/2024.12.24.629435
Open publication

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Virus-free continuous directed evolution in human cells using somatic hypermutationDOI 10.1101/2024.12.24.629435
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