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Article

Protein evolution with an expanded genetic code

11 Nov 2008

Abstract excerpt

We have devised a phage display system in which an expanded genetic code is available for directed evolution. This system allows selection to yield proteins containing unnatural amino acids should such sequences functionally outperform ones containing only the 20 canonical amino acids. We have optimized this system for use with several unnatural amino acids and provide a demonstration of its utility through the...

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Identifiers

PMID: 19004806
DOI: 10.1073/pnas.0809543105

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