Article

A library-on-library screen reveals the breadth expansion landscape of a broadly neutralizing betacoronavirus antibody

2024-06-10

Abstract excerpt

<h4>ABSTRACT</h4> Broadly neutralizing antibodies (bnAbs) typically evolve cross-reactivity breadth through acquiring somatic hypermutations. While evolution of breadth requires improvement of binding to multiple antigenic variants, most experimental evolution platforms select against only one antigenic variant at a time. In this study, a yeast display library-on-library approach was applied to delineate the affi...

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Literature Corpus work: c7018cbb-93be-5c60-9eea-f8180a1915e2
DOI: 10.1101/2024.06.06.597810

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