Article

Rapid generation of potent antibodies by autonomous hypermutation in yeast

2020-11-11

Abstract excerpt

The predominant approach for antibody generation remains animal immunization, which can yield exceptionally selective and potent antibody clones owing to the powerful evolutionary process of somatic hypermutation. However, animal immunization is inherently slow, has poor compatibility with certain antigens ( e . g ., integral membrane proteins), and suffers from self-tolerance and immunodominance, which limit th...

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Literature Corpus work: 9f82b849-739c-5d18-9861-2f54bbedd82f
DOI: 10.1101/2020.11.11.378778

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