Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Restoring the potency of a neutralizing antibody via guided hypermutation with hyper-antibody editor HAE1.

Genome research - 6 May 2026

Wang Yuhong, Guo Yuefeng, Lu Qiuyu, Liu Xinyi, Xu Haoqi, Chen Jiayi, Pi Ruiqi, Yuan Shaopeng, Yang Ziting, Lu Rusen, Meng Fei-Long, Gan Tingting, Hu Jiazhi

Abstract excerpt

Somatic hypermutation (SHM) drives antibody affinity maturation in B cells. By mimicking this process, guided hypermutation (GHM) tools employing CRISPR systems and activation-induced cytidine deaminase (AID) have advanced antibody development. However, GHM-induced mutations in cultured cells exhibit mutation patterns distinct from those observed in natural antibody diversification following in vivo affinity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Neutralizing
Share to Antibodies, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to COVID-19

Share to CRISPR-Cas Systems

Share to Cytidine Deaminase

Share to HEK293 Cells

Share to SARS-CoV-2

Share to Somatic Hypermutation, Immunoglobulin

Source

Identifiers

PMID: 41856683
DOI: 10.1101/gr.281396.125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Restoring the potency of a neutralizing antibody via guided hypermutation with hyper-antibody editor HAE1.PMID 41856683Read ↗

Intrinsic Nucleotide Preference of Diversifying Base Editors Guides Antibody Ex Vivo Affinity MaturationSemantic proximity Read ↗

Dissecting the impact of somatic hypermutation on SARS-CoV-2 neutralization and viral escapeSemantic proximity Read ↗

Somatic hypermutation introduces bystander mutations that prepare SARS-CoV-2 antibodies for emerging variants.Semantic proximity Read ↗

<i>In vivo</i> affinity maturation of murine B cells reprogrammed to express human antibodiesSemantic proximity Read ↗

Functional diversification of hybridoma produced antibodies by CRISPR/HDR genomic engineeringSemantic proximity Read ↗

Somatic evolution of a cross-reactive germline antibody that expands its breadth to neutralize new SARS-CoV-2 variantsSemantic proximity Read ↗

Design of Antigen-Specific Antibody CDRH3 Sequences Using AI and Germline-Based TemplatesSemantic proximity Read ↗

Exceptional Antibodies Produced by Successive Immunizations.Semantic proximity Read ↗

Nucleotide Insertions and Deletions Complement Point Mutations to Massively Expand the Diversity Created by Somatic Hypermutation of AntibodiesSemantic proximity Read ↗

Virus-free continuous directed evolution in human cells using somatic hypermutationSemantic proximity Read ↗

Potent SARS-CoV-2 neutralizing antibodies selected from a human antibody library constructed decades agoSemantic proximity Read ↗

EASINESS: E. coli Assisted Speedy affINity-maturation Evolution SyStem.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.