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Article

Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays.

Advanced biology - 1 Mar 2021

Ronchi Silvia, Buccino Alessio Paolo, Prack Gustavo, Kumar Sreedhar Saseendran, Schröter Manuel, Fiscella Michele, Hierlemann Andreas

Abstract excerpt

Recent advances in the field of cellular reprogramming have opened a route to studying the fundamental mechanisms underlying common neurological disorders. High-density microelectrode-arrays (HD-MEAs) provide unprecedented means to study neuronal physiology at different scales, ranging from network through single-neuron to subcellular features. In this work, HD-MEAs are used in vitro to characterize and compare...

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PMID: 33729694
DOI: 10.1002/adbi.202000223
PMCID: PMC7610355

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