Article

Massively Parallel Reporter Assay Confirms Regulatory Potential of hQTLs and Reveals Important Variants in Lupus and Other Autoimmune Diseases

2023-08-18

Abstract excerpt

<h4>Objective</h4> To systematically characterize the potential for histone post-translational modifications, i.e., histone quantitative trait loci (hQTLs), expression QTLs (eQTLs), and variants on systemic lupus erythematosus (SLE) and autoimmune (AI) disease risk haplotypes to modulate gene expression in an allele dependent manner. <h4>Methods</h4> We designed a massively parallel reporter assay (MPRA) contain...

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Literature Corpus work: 27bbec14-b75e-5435-8ac5-7ae202cca1c2
DOI: 10.1101/2023.08.17.553722

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