Article

Histone deacetylase inhibition mitigates cognitive deficits and astrocyte dysfunction induced by Aβ oligomers

2023-10-30

Abstract excerpt

<h4>ABSTRACT</h4> Inhibitors of histone deacetylases (iHDACs) are promising drugs for neurodegenerative diseases. We have evaluated the therapeutic potential of the new iHDAC6 LASSBio-1911 in Aβ oligomer (AβO) toxicity models and astrocytes, key players in neuroinflammation and Alzheimer’s disease (AD). Astrocyte phenotype and synapse density were evaluated by flow cytometry, Western blotting, immunofluorescence...

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Literature Corpus work: 0b731169-e06a-57d8-a69f-6d3ccc832a20
DOI: 10.1101/2023.10.25.564038

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