Article

Deletion of TNFR1 in astrocytes restores memory in aged Alzheimer’s disease mice

2026-04-04

Abstract excerpt

Astrocytes participate in local inflammation and cognitive decline in Alzheimer’s disease (AD). Aberrant cytokine TNFα signaling via astrocyte type-1 receptor (aTNFR1) could causally link the two AD pathology aspects. To verify this hypothesis, we crossed transgenic AD mice with mice enabling astrocyte-specific conditional TNFR1 deletion (aTNFR1KO). Induction of aTNFR1KO at early AD stages, preserved memory and re...

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Literature Corpus work: 3cb56bc2-8ca2-5477-83ee-609c8cc66ff0
DOI: 10.64898/2026.04.02.716130

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