Article

Peptides alleviate cognitive impairment by inhibiting and disassembling amyloid-β aggregates in Alzheimer’s disease

2025-06-01

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is a devasting neurodegenerative disorder characterized by β-amyloid formation, further exacerbated by RIPK1/RIPK3 necrosome-induced programmed necrosis (necroptosis). We previously showed that the RIPK1/RIPK3 necrosome forms a functional amyloid complex using its RIP homotypic interaction motifs (RHIMs). Here, we discovered that the core RIPK1/RIPK3 necrosome shares str...

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Literature Corpus work: 5f91a79f-4522-555e-b0cc-6bf0b337fa1b
DOI: 10.1101/2025.05.28.656730

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