Unique molecular characteristics and microglial origin of Kv1.3 channel–positive brain myeloid cells in Alzheimer’s disease

Abstract excerpt

Significance The potassium channel Kv1.3 in brain myeloid cells represents a promising therapeutic target for Alzheimer’s disease (AD). The patterns of expression and functional roles of Kv1.3 channels in brain myeloid subpopulations and the microglial-versus-peripheral myeloid origin of Kv1.3-expressing cells in AD remain unclear. Here, we show that in mice, Kv1.3 is selectively up-regulated in an Aβ-dependent...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alzheimer's disease research and treatments
• Share to Neurogenesis and neuroplasticity mechanisms
• Share to Neuroinflammation and Neurodegeneration Mechanisms