Article
Kv1.3 Blockade Alleviates White Matter Injury through Reshaping M1/M2 Phenotypes via the NF-κB Signaling Pathway after Intracerebral Hemorrhage.
Journal of integrative neuroscience - 5 Dec 2023
Wang Bo, Chen Jie, Wang Shuhong, Chen Lin, Zhang Xuyang, Zhou Tengyuan, Zhong Jun, Zhang Chao, He Yijia, Zuo Yonglin, Feng Hua, Yin Yi, Ge Hongfei
Abstract excerpt
BACKGROUND: White matter injury (WMI) in basal ganglia usually induces long-term disability post intracerebral hemorrhage (ICH). Kv1.3 is an ion channel expressed in microglia and induces neuroinflammation after ICH. Here, we investigated the functions and roles of Kv1.3 activation-induced inflammatory response in WMI and the Kv1.3 blockade effect on microglia polarization after ICH. METHODS: Mice ICH model was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.