Article

MSH2 and MSH6 as size dependent cellular determinants for prime editing in human embryonic stem cells

2022-08-17

Abstract excerpt

<h4>Summary</h4> Potential applications of precise genome editing in human pluripotent stem cells (hPSCs), not only for isogenic disease modeling but also for ex vivo stem cell therapy, have urged the application of diverse genome editing tools in hPSCs. However, unlike differentiated somatic cells, the unique cellular properties of hPSCs (e.g., high susceptibility to DNA damage and active DNA repair) largely de...

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Literature Corpus work: 1b52cc91-33e5-5d10-a1e3-acf13a122b28
DOI: 10.1101/2022.08.17.504216

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