High Shear Stress Reduces ERG Causing Endothelial-Mesenchymal Transition and Pulmonary Arterial Hypertension

Abstract excerpt

<h4>ABSTRACT</h4> Pathological high shear stress (HSS, 100 dyn/cm 2 ) is generated in distal pulmonary arteries (PA) (100-500 μm) in congenital heart defects and in progressive PA hypertension (PAH) with inward remodeling and luminal narrowing. Human PA endothelial cells (PAEC) were subjected to HSS versus physiologic laminar shear stress (LSS, 15 dyn/cm 2 ). Endothelial-mesenchymal transition (EndMT), a featur...

Topics

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• Endothelial Cells
• Blood Flow Velocity
• Chromatin
• Gene Silencing
• Kruppel-Like Transcription Factors
• Nitric Oxide Synthase Type III
• Pulmonary Hypertension Research and Treatments
• Regulatory Sequences, Nucleic Acid

Identifiers and source

Literature Corpus work

0b2028ad-e26d-5b04-9f42-b91c28015528

DOI

10.1101/2024.02.02.578526