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Article

In Vivo Function of Flow-Responsive Cis-DNA Elements of eNOS Gene: A Role for Chromatin-Based Mechanisms.

Circulation - 3 Aug 2021

Ku Kyung Ha, Dubinsky Michelle K, Sukumar Aravin N, Subramaniam Noeline, Feasson Manon Y M, Nair Ranju, Tran Eileen, Steer Brent M, Knight Britta J, Marsden Philip A

Abstract excerpt

BACKGROUND: eNOS (endothelial nitric oxide synthase) is an endothelial cell (EC)-specific gene predominantly expressed in medium- to large-sized arteries where ECs experience atheroprotective laminar flow with high shear stress. Disturbed flow with lower average shear stress decreases eNOS transcription, which leads to the development of atherosclerosis, especially at bifurcations and curvatures of arteries. This...

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PMID: 33910388
DOI: 10.1161/CIRCULATIONAHA.120.051078

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