Article

Shear Stress Initiates Endothelial to Mesenchymal Transition in Endocardial Endothelial Cells

2022-12-08

Abstract excerpt

Discrete subaortic stenosis (DSS) is a congenital heart disease in which a fibrotic membrane forms below the aortic valve; the underlying cellular mechanisms are currently unknown. Since an elevated pressure gradient in the left ventricular outflow tract (LVOT) is a distinguishing feature of DSS, it is hypothesized that the membrane formation is caused by elevated wall shear stress applied to the endocardial endot...

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Literature Corpus work: d4194208-4cb6-5ab6-bde0-272465a72bec
DOI: 10.1101/2022.12.05.519049

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