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Article

Serial analysis of the vascular endothelial transcriptome under static and shear stress conditions

28 May 2008

Abstract excerpt

We have utilized serial analysis of gene expression (SAGE) to analyze the response of human coronary artery endothelial cells (HCAECs) to laminar shear stress (LSS). Primary cultures of HCAECs were exposed to 15 dyn/cm(2) LSS for 24 h in a parallel plate flow chamber and compared with identical same passage cells cultured under static conditions. The expression levels of a number of functional categories of genes...

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PMID: 18505769
DOI: 10.1152/physiolgenomics.90201.2008

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