Article

Shear-Induced Macrophage Secretome Promotes Endothelial Permeability

2025-06-26

Abstract excerpt

<h4>Background</h4> Discrete subaortic stenosis (DSS) is a pediatric cardiovascular disease marked by fibrotic growth within the left ventricular outflow tract (LVOT), leading to severe complications, including left ventricular hypertrophy, aortic regurgitation, and arrhythmias. Despite surgical intervention, a 20-30% recurrence rate suggests a complex underlying pathophysiology. Elevated flow and resultant hemod...

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Literature Corpus work: 5940ae85-1121-5456-a538-861666b818e9
DOI: 10.1101/2025.06.20.660831

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