Article
Towards a map of cis-regulatory sequences in the human genome.
Nucleic acids research - 20 Jun 2018
Niu Meng, Tabari Ehsan, Ni Pengyu, Su Zhengchang
Abstract excerpt
Accumulating evidence indicates that transcription factor (TF) binding sites, or cis-regulatory elements (CREs), and their clusters termed cis-regulatory modules (CRMs) play a more important role than do gene-coding sequences in specifying complex traits in humans, including the susceptibility to common complex diseases. To fully characterize their roles in deriving the complex traits/diseases, it is necessary to...
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