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Article

Pooled ChIP-Seq Links Variation in Transcription Factor Binding to Complex Disease Risk.

Cell - 21 Apr 2016

Tehranchi Ashley K, Myrthil Marsha, Martin Trevor, Hie Brian L, Golan David, Fraser Hunter B

Abstract excerpt

Cis-regulatory elements such as transcription factor (TF) binding sites can be identified genome-wide, but it remains far more challenging to pinpoint genetic variants affecting TF binding. Here, we introduce a pooling-based approach to mapping quantitative trait loci (QTLs) for molecular-level traits. Applying this to five TFs and a histone modification, we mapped thousands of cis-acting QTLs, with over 25-fold...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27087447
DOI: 10.1016/j.cell.2016.03.041
PMCID: PMC4842172

Genes

CTCF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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