Article

Learning induces persistent chromatin loops underlying robust gene expression during memory recall

2025-09-30

Abstract excerpt

Long-term memories are stored in neuronal ensembles called engrams, but the existence of persistent molecular traces in nuclei of engram neurons remain unknown. Using activity-dependent nuclear tagging in vivo , we profiled higher-order chromatin folding and DNA methylation in thousands of single hippocampal neurons up to a month after contextual fear conditioning (CFC). We find CFC-induced chromatin loop plastic...

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Literature Corpus work: a75016b8-6647-5665-a756-2149dfe8c8cd
DOI: 10.1101/2025.09.30.678146

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