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Extracellular vesicles from stem cells rescue cellular phenotypes and behavioral deficits in SHANK3-associated ASD neuronal and mouse models.

Cell death & disease - 22 Feb 2026

Choudhary Ashwani, Rosh Idan, Hussein Yara, Netser Shai, Shemen Aviram, Suliman Taghreed, Rike Wote Amelo, Simchi Lilach, Shklyar Boris, Abu-Akel Ahmad, Zinger Assaf, Offen Daniel, Wagner Shlomo, Stern Shani

Abstract excerpt

Extracellular vesicles (EVs) are lipid bilayer-enclosed structures that mediate intercellular communication by transferring diverse cargoes, including RNA and proteins. SHANK3, a synaptic scaffolding protein critical for synapse structure and function, is implicated in autism spectrum disorder (ASD) and Phelan-McDermid Syndrome (PMS). Early hyperexcitability in cortical neurons is a characterized endophenotype in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41723111
DOI: 10.1038/s41419-026-08474-x
PMCID: PMC12966433

Genes

ACTB
AGRN
C1R
C1S
CFL1
CLSTN1
FGF2
IGFBP3
MDK
SFRP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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