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Article

Analysis of how antigen mutations disrupt antibody binding interactions toward enabling rapid and reliable antibody repurposing.

mAbs - 1 Dec 2025

Islam Sumaiya, Chauhan Varun M, Pantazes Robert J

Abstract excerpt

Antibody repurposing is the process of changing a known antibody so that it binds to a mutated antigen. One of the findings to emerge from the Coronavirus Disease 2019 (COVID-19) pandemic was that it was possible to repurpose neutralizing antibodies for Severe Acute Respiratory Syndrome, a related disease, to work for COVID-19. Thus, antibody repurposing is a possible pathway to prepare for and respond to future...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39690439
DOI: 10.1080/19420862.2024.2440586
PMCID: PMC11657118

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