Article
Analysis of how antigen mutations disrupt antibody binding interactions toward enabling rapid and reliable antibody repurposing.
mAbs - 1 Dec 2025
Islam Sumaiya, Chauhan Varun M, Pantazes Robert J
Abstract excerpt
Antibody repurposing is the process of changing a known antibody so that it binds to a mutated antigen. One of the findings to emerge from the Coronavirus Disease 2019 (COVID-19) pandemic was that it was possible to repurpose neutralizing antibodies for Severe Acute Respiratory Syndrome, a related disease, to work for COVID-19. Thus, antibody repurposing is a possible pathway to prepare for and respond to future...
Topics
- Humans
- SARS-CoV-2
- COVID-19
- Antibodies, Neutralizing
- Mutation
- Drug Repositioning
- Protein Binding
- Antigen-Antibody Complex
- Antibodies, Viral