Article

Unique Binding and Stabilization Mechanisms Employed By and Engineered Into Nanobodies

2023-10-22

Abstract excerpt

Nanobodies are single domain antibody variants that bind an antigen with the precision and affinity of a conventional antibody at only a fraction of their size. In solving the crystal structures of our nanobody-GFP complexes and compared with other available structures, we uncover mechanism that enable nanobodies to function so efficiently and effectively as single-domain antibodies. We show that unlike convention...

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Literature Corpus work: 9a1ba2f1-f1b9-57e3-b50c-6c0d76bc5513
DOI: 10.1101/2023.10.22.563475

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