Article

Harnessing protein-folding algorithms to drug intrinsically disordered epitopes

2025-11-13

Abstract excerpt

Due to their lack of a specific structure and dynamical nature, targeting of epitopes that are part of an intrinsically disordered region of a protein is a notoriously difficult task. Here, we describe a computational approach to overcome this problem, based on the use of a protein-folding algorithm and its confidence metrics within a Monte Carlo optimization pipeline to generate peptide-based binders. For differe...

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Literature Corpus work: 5862912e-e598-544a-9d07-8531091b655d
DOI: 10.1101/2025.11.11.687846

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