Article

The skin environment controls local dendritic cell differentiation and function through innate IL-13

2021-01-06

Abstract excerpt

<h4>ABSTRACT</h4> The signals driving the adaptation of type-2 dendritic cells (DC2s) to diverse peripheral environments are not well understood. We show that the development of CD11b low migratory DC2s, a DC2 population unique to the dermis, requires STAT6- and KLF4-dependent IL-13 signaling, whereas DC2s in lung and small intestine are STAT6-independent. Dermal IL-13 is mostly derived from innate lymphoid cell...

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Literature Corpus work: 0acd8c7f-83fe-5b0b-a5d4-bf3296f108f5
DOI: 10.1101/2021.01.05.425466

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