Article
A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.
The Journal of experimental medicine - 16 Dec 2013
Salimi Maryam, Barlow Jillian L, Saunders Sean P, Xue Luzheng, Gutowska-Owsiak Danuta, Wang Xinwen, Huang Li-Chieh, Johnson David, Scanlon Seth T, McKenzie Andrew N J, Fallon Padraic G, Ogg Graham S
Abstract excerpt
Type 2 innate lymphoid cells (ILC2s, nuocytes, NHC) require RORA and GATA3 for their development. We show that human ILC2s express skin homing receptors and infiltrate the skin after allergen challenge, where they produce the type 2 cytokines IL-5 and IL-13. Skin-derived ILC2s express the IL-33 receptor ST2, which is up-regulated during activation, and are enriched in lesional skin biopsies from atopic patients....
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