Article

Structural and mechanistic insights into Dis3L2–mediated degradation of structured RNA

2025-08-02

Abstract excerpt

The RNase II/RNB family of exoribonucleases is present in all domains of life and includes three main eukaryotic members, the Dis3-like proteins (Dis3, Dis3L1, Dis3L2). At the cellular level, Dis3L2 is distinguished by the unique preference for uridylated RNA substrates and the highest efficiency in degrading double-stranded RNA. Defects in these enzymes have been linked to some types of cancers and overgrowth dis...

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Literature Corpus work: 0ac5d796-d82f-5a09-b5dc-8f2d66cb2c95
DOI: 10.1101/2025.08.01.668158

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