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Article

Modulating the RNA processing and decay by the exosome: altering Rrp44/Dis3 activity and end-product.

PloS one - 1 Jan 2013

Reis Filipa P, Barbas Ana, Klauer-King A A, Tsanova Borislava, Schaeffer Daneen, López-Viñas Eduardo, Gómez-Puertas Paulino, van Hoof Ambro, Arraiano Cecília M

Abstract excerpt

In eukaryotes, the exosome plays a central role in RNA maturation, turnover, and quality control. In Saccharomyces cerevisiae, the core exosome is composed of nine catalytically inactive subunits constituting a ring structure and the active nuclease Rrp44, also known as Dis3. Rrp44 is a member of the ribonuclease II superfamily of exoribonucleases which include RNase R, Dis3L1 and Dis3L2. In this work we have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24265673
DOI: 10.1371/journal.pone.0076504
PMCID: PMC3827031

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