Article
A single subunit, Dis3, is essentially responsible for yeast exosome core activity.
Nature structural & molecular biology - 1 Jan 2007
Dziembowski Andrzej, Lorentzen Esben, Conti Elena, Séraphin Bertrand
Abstract excerpt
The conserved core of the exosome, the major eukaryotic 3' --> 5' exonuclease, contains nine subunits that form a ring similar to the phosphorolytic bacterial PNPase and archaeal exosome, as well as Dis3. Dis3 is homologous to bacterial RNase II, a hydrolytic enzyme. Previous studies have suggested that all subunits are active 3' --> 5' exoRNases. We show here that Dis3 is responsible for exosome core activity....
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