Article

Modeling human limb skeletal development using human pluripotent stem cell-derived skeletal assembloids

2025-01-10

Abstract excerpt

<h4>SUMMARY</h4> Despite recent advances in pluripotent stem cell-based approaches to induce skeletal cells, recapitulating human limb skeletal development in terms of structure and longitudinally oriented growth remains an unresolved challenge. Here, we report a method to differentiate human pluripotent stem cells into region-specific skeletal organoids harboring GDF5 + PRG4 + interzone/articular chondrocyte p...

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Literature Corpus work: 0aadd296-3792-5460-80e0-114984994481
DOI: 10.1101/2025.01.09.631479

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