Recapitulation of human endochondral ossification by SOX9+ sclerotomal progenitors.

Abstract excerpt

<title>Abstract</title> <p>Endochondral ossification generates most of the load-bearing bones during skeletal development. Fully recapitulating it in human cells remains a challenge. Here, we established a toolkit to derive near uniform (>99%) <italic>SOX9</italic>⁺ sclerotomal progenitors (scl-progenitors), a key bipotent mesenchymal precursor at the pre-condensation stage, from human pluripotent stem...

Topics

Open a Topic to create a Post that cites this publication.

• Bone and Bones
• Bone health and treatments
• Cartilage
• Developmental Biology and Gene Regulation
• Heterotopic Ossification and Related Conditions
• Medical Imaging and Pathology Studies
• Osteoarthritis Treatment and Mechanisms
• Pluripotent Stem Cells Research

Identifiers and source

Literature Corpus work

7c058150-bb22-592f-8080-6312388ad64e

DOI

10.21203/rs.3.rs-3874372/v1