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Modeling of skeletal development and diseases using human pluripotent stem cells

5 Nov 2024

Abstract excerpt

Human skeletal elements are formed from distinct origins at distinct positions of the embryo. For example, the neural crest produces the facial bones, the paraxial mesoderm produces the axial skeleton, and the lateral plate mesoderm produces the appendicular skeleton. During skeletal development, different combinations of signaling pathways are coordinated from distinct origins during the sequential developmental...

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PMID: 39498496
DOI: 10.1093/jbmr/zjae178

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